Science & Technology

India’s first mRNA vaccine against Omicron

GEMCOVAC-OM, India’s first indigenous mRNA vaccine for the Omicron variant of the novel coronavirus, was approved under emergency use guidelines by the Drug Controller General of India (DCGI). 

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About GEMCOVAC-OM:

  • Developed by: Pune-based Gennova Biopharmaceuticals Ltd. 
  • GEMCOVAC-OM is touted to be stable in a 2-8 degrees Celsius range and hence could be stored in ordinary refrigerators. 
  • It could be administered into the skin via a “needle-free” PharmaJet system.

mRNA vaccines:

  • mRNA vaccines use a small piece of synthetic mRNA (messenger RNA) that encodes the instructions for making a viral protein.
    • The mRNA in the vaccine is a single-stranded RNA molecule that provides the blueprint for the production of a specific viral protein (spike protein in the case of COVID-19).
    • Once the mRNA is injected into the body, cells take up the mRNA and use it to produce the viral protein. This protein then triggers an immune response, leading to the production of antibodies and the activation of immune cells. 
  • The purpose of mRNA vaccines is to stimulate an immune response without causing the actual disease. 
What is mRNA? The messenger molecule that's been in every living cell for  billions of years is the key ingredient in some COVID-19 vaccines

Advantages:

  • As mRNA vaccines are not developed from an active pathogen or an inactivated pathogen, they are non-infectious. 
  • RNA vaccines can be produced faster and cheaper as compared to conventional/ traditional vaccines. 
  • Replication mechanism can amplify antigen translation, decreasing the amount of starting material needed. It can be produced with fewer error rates. 
  • According to preliminary trial results, these vaccines produce a reliable immune response and can be tolerated by healthy individuals with few side effects.

Risks of mRNA vaccine:

  • mRNA vaccines are new. Thus, there is the risk of unknown effects, both short and longer-term.
  • Some mRNA-based vaccines are associated not only with inflammation but also potentially with autoimmunity. 
  • The m-RNA molecule and lipid nanoparticle transport molecule is very fragile, and thus the vaccine must be kept at very low temperatures (minus 70-to-minus 80 degree Celsius) to avoid degrading.  

Comparison of mRNA and DNA vaccine:

Similarities:

  • Both vaccines deliver the message to cells to create desired protein so the immune system creates a response against this protein.
  • Both produce a specific portion of the virus - spike protein in the case of coronavirus.
  • Both are laboratory-made structures and not obtained from the actual virus.
  • Both are being touted for their cost-effectiveness and ability to be developed more quickly than traditional, protein vaccines.
    • Traditional vaccines often rely on actual viruses or viral proteins grown in eggs or cells and can take years and years to develop.
  • Both can theoretically be made more readily available because they rely on genetic code–not a live virus or bacteria. This also makes them cheaper to produce.

Differences:

  • DNA is much easy to prepare in the laboratory. The DNA-based vaccine will be around 10 times cheaper.
  • m-RNA based vaccine uses Ribosome in the cytoplasm to produce the spike protein. DNA must enter the nucleus of the cell to produce the spike protein. Since, in the case of DNA vaccine, entry into the nucleus is required, so, safety concerns are more. 

Telegram Bots

Context: Reports surfaced stating that a Telegram bot was able to retrieve and display identification numbers from vaccination documents, including Aadhaar. Similarly, in 2021, a bot on the platform was discovered selling phone numbers extracted from Facebook. According to security researchers, a network of deep fake bots was identified on the platform, generating nonconsensual images using images of individuals submitted by users.

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What are Bots?

  • A bot refers to a computer program designed to carry out tasks automatically.
  • Its primary purpose is to gather information from the internet or execute repetitive tasks at a much faster pace. 

Applications of Bots

Ranging from malicious bots that carry viruses to search engine spiders. 

  • Chatbots are capable of engaging in conversations with users to accomplish specific objectives. Example: Hi Poncho chatbot available in Facebook Messenger tells you the weather around you.
  • Web spidering, where an automated script fetches, analyzes, and organizes data from web servers at a speed far exceeding human capability.
  • Automated tasks such as setting alarms, providing weather updates, or conducting online searches. Examples: Siri and Cortana; Microsoft's Clippy.
  • One app with multiple bots can help with different tasks, like ordering food or checking sports scores.
  • Artificial intelligence-based bots are increasingly being used by organizations and entities to provide customer care, and sales and marketing services.

Two sides to bots

  • Beneficial purposes: information gathering, automated interaction through instant messaging or web interfaces, and dynamic engagement with websites.
  • However, Norton defines malicious bots as self-propagating malware that infects a host and establishes connections with central servers.
  • Can perform actions such as collecting passwords, logging keystrokes, acquiring financial information, distributing spam, and exploiting vulnerabilities created by viruses and worms.
  • Bots associated with automated accounts on Twitter and Facebook, spread misinformation on these platforms.

Use of Bots for malicious purposes

Bot attacks have impacted over 94.2% of websites. These attacks involve various types of malicious bots and botnets, including:

  • Spambots that harvest email addresses from contact
  • Downloader programs that suck bandwidth by downloading entire websites
  • Viruses and worms
  • DDoS attacks: distributed denial-of-service (DDoS) attack is a malicious attempt to disrupt the normal traffic of a targeted server, service, or network 
  • Bots are used to increase traffic counts on analytics reporting to extract money from advertisers. 
  • Internet trolls: Bots may be used on Internet forums to automatically post inflammatory or nonsensical posts to disrupt the forum and anger users.  

What is Telegram?

  • Telegram, introduced in 2013, is a messaging platform service that provides an API for developers to create their applications and utilize the free API to develop specialized tools like bots, enabling seamless integration of services.
  • It ranks among the top 10 most downloaded apps globally and is recognized for its capacity to facilitate file sharing of up to 2GB.
  • It ensures the privacy of conversations by safeguarding them against unauthorized access from entities such as officials, marketers, and advertisers.
  • It does not handle any requests related to group chats or private conversations among participants.

Telegram bots 

  • Telegram bots possess the capability to host complete web applications, enabling the provision of a wide range of services, from online stores to arcade games.
  • Some bots have the potential to collect user data, including personal information and chat history.
  • They can be specifically designed to facilitate convenient access to information stored in extensive databases that they are connected to.

Security concerns regarding telegram bots

  • Certain bots may possess security vulnerabilities that can be exploited by threat actors, compromising the security of users.
  • Threat actors can create malicious bots that contain harmful content, such as links to phishing websites or malware.
  • These threat actors may distribute bots with the intention of scamming users, enticing them with promises of rewards or discounts to trick them into divulging their personal information. 
  • Introducing a bot into a secure Telegram chat may potentially weaken the level of encryption.
  • Wired reported that some bots do not employ Telegram's encryption protocol, which scrambles and renders messages illegible during transit. 

Precautions and remedies 

  • Anti-bot technique: Use of CAPTCHA, which is a form of Turing test used to distinguish between a human user and a less-sophisticated AI-powered bot, by the use of graphically-encoded human-readable text. However, Captchas are not foolproof in preventing bots as they can often be circumvented by computer character recognition and security holes.
  • Anti-malware software: All software should be updated and system updates should not be ignored.
  • To understand how individual bots handle user data, it is advisable for users to carefully review the terms of service and privacy policy associated with each bot.

Gut Microbiome

Context: A recent study conducted by researchers from a Japanese university compared the gut microbiota of older healthy individuals in two Japanese cities. The findings indicate a potential connection between gut microbiota and longevity.

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About Gut microbiome

  • Also known as gut microbiota or gut flora.
  • It is the microorganisms, including bacteria, viruses, fungi, and other microbes, that reside in the gastrointestinal tract, particularly in the large intestine.

Composition of gut microbiome

  • Microbial colonization of the human gut begins at birth.
  • The types of microorganisms in our gut can differ depending on where they are in the digestive system. 
  • The colon, which is part of the large intestine, has the most microorganisms compared to any other part of our body.
  • Factors such as diet, lifestyle, medications (especially antibiotics), stress, and certain diseases can influence the composition and diversity of the gut microbiota. 

Role of gut microbiome in our bodies

  • Digestion and Nutrient Absorption: Certain bacteria in the gut help break down dietary fibers and other complex carbohydrates that our body cannot digest on its own. They produce enzymes that break down these compounds into simpler molecules that can be absorbed and utilised by our bodies.
  • Immune System Function: A balanced and diverse microbiota helps maintain a healthy immune system, protecting against pathogens and reducing the risk of autoimmune diseases.
  • Metabolism and Energy Regulation: Studies have shown that the composition of gut microbiota can influence our metabolism and energy balance. Imbalances in the gut microbiota have been associated with metabolic disorders such as obesity and type 2 diabetes.
  • Synthesis of Vitamins and Beneficial Compounds: Some gut bacteria are capable of producing vitamins, such as vitamin K and certain B vitamins, that our bodies cannot produce on their own. 

Brain-Gut Axis: The gut microbiota communicates bidirectionally with the brain through the gut-brain axis. This connection influences various aspects of brain function, including mood regulation, stress response, and cognitive function. One particular metabolite(a substance formed in or necessary for metabolism), butyrate, has emerged as a crucial element in promoting brain health through the gut-brain axis.

More about Brain Gut Axis

  • Butyrate is produced when “good” bacteria in gut help the body break down dietary fiber in large intestine (colon). It’s one of several short-chain fatty acids, which are named for their chemical structure.
  • Butyrate being the single most demarcating factor between the longest living and the shortest life span.

E-education platforms, their Generative AI chapter

Context: The Massive Open Online Courses have gained a lot of currency in the last one decade. However, use of Artificial Intelligence has provided impetus to the growth of MOOCs in the recent years.

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Background of MOOCs

  • Between 2008-2011, a new genre of online courses titled ‘Massive Open Online Courses’ (MOOCs) made their entry, driven by reputed institutions of learning. 
  • Stanford University in 2011 brought first institutional course using MOOC model.
  • Most known and famous MOOC was edX launched by Harvard and MIT in joint effort. 
  • As of 2021, there existed nearly 35 MOOCS Learning Management Systems (LMS) spread across North America, Asia and Europe.
  • India’s ‘Study Webs of Active-Learning for Young Aspiring Minds’ (SWAYAM) launched in 2017 by the Ministry of Education, Government of India. It is one of the world’s largest learning e-portals.

Challenges faced by MOOCs

  • Fragile financial situation
  • Very high operating cost and maintenance expenses
  • Steep marketing cost
  • Very low and competitive fee structure
  • High dropout rates by entry level learners.

However, in the recent years, artificial intelligence has become a vital tool to make MOOC more interactive and attractive as a platform. In the current case Generative Artificial Intelligence has made an impressive performance in retaining the utility of the MOOCs.

What is Generative AI?

  • Generative artificial intelligence refers to a subset of AI techniques and models that are designed to generate new content or data that is similar to, or indistinguishable from, real human-generated content. It involves training models to learn patterns and structures from existing data and then using that knowledge to generate new, original content.
  • Generative AI models can be used in various applications such as image synthesis, text generation, music composition, and even video generation. These models are often based on deep learning techniques, particularly generative models such as generative adversarial networks (GANs), variational autoencoders (VAEs), or transformers.
  • GANs, for example, consist of two components: a generator and a discriminator. The generator learns to generate new data samples, such as images, by trying to fool the discriminator into thinking that the generated samples are real. The discriminator, on the other hand, learns to distinguish between real and generated data. Through an iterative process of training and feedback, GANs can produce increasingly realistic and high-quality content.
  • Generative AI has shown significant advancements in recent years and has been used in a wide range of applications, including art and design, content creation, data augmentation, and even in the development of realistic deepfake videos. However, it's important to note that generative AI also raises ethical concerns, such as the potential for misuse, the creation of misleading content, and the need for responsible and ethical deployment.

Examples of Generative AI:

  • OpenAI's Generative Pre-trained Transformer (GPT)
  • DeepArt or Deepfakes

How Generative AI could be game changer in MOOCs?

  • It help students easily locate the suitable courses without any attempt to explore entire MOOC.
  • AI can give challenges and task to students on daily basis without any repetition in language or pattern.
  • AI coaching, counselling and virtual assistance. AI techniques like natural language processing (NLP) enable chatbots and virtual assistants to interact with students, answer their questions, and provide support.
  • AI can assist in content creation and curation for online courses.
  • AI can help in making learning more interesting, thereby retaining high enrolment ratios. 
  • AI can analyze student data, such as performance, learning styles, and preferences, to create personalized learning experiences. Adaptive learning platforms can use AI algorithms to tailor educational content and resources to each student's individual needs.
  • AI can help in breaking down the language barrier in real-time. 

India-Norway Space Cooperation

Context: Norwegian Ambassador’s visit to the Indian Space Research Organisation (ISRO) headquarters offers an occasion to recall the launch of Rohini RH-300 Mk-II, the challenging mission which took place 26 years ago at Ny-Alesund, Svalbard.

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About Rohini RH-300 Mk-II

  • It is a single-stage sounding rocket, derived from French Belier rocket engine technology. 
  • It was part of the Rohini family of sounding rockets developed by ISRO’s Vikram Sarabhai Space Centre (VSSC) in Thiruvananthapuram.
  • It rose to the skies from Svalbard, Norway, an archipelago situated in the Arctic Ocean, operationalising a new rocket launching range there.

The RH-300 Mk-II was given a new name by the NSC (Norwegian Space Centre): Isbjorn-1, which translates literally as ‘Polar Bear-I.’

About Sounding Rocket

  • Sounding rockets are one or two-stage solid propellant rockets used for probing the upper atmospheric regions and for space research. 
  • They also serve as easily affordable platforms to test or prove prototypes of new components or subsystems intended for use in launch vehicles and satellites.
  • It is used for a variety of scientific purposes, including atmospheric research, astronomy, microgravity experiments, and space technology testing.
  • The first sounding rocket to be launched from Thumba was the American Nike-Apache in 1963. 

DRDO successfully tests ballistic missile ‘Agni Prime’

Context: The new generation ballistic missile ‘Agni Prime’ was successfully flight-tested by Defence Research and Development Organisation (DRDO) from Dr. A.P.J. Abdul Kalam Island off Odisha.

Agni series of missiles

  • The Agni series of missiles is a family of long-range, surface-to-surface ballistic missiles that can carry nuclear bombs.
  • Developed by: Defence Research and Development Organisation
  • There are currently six operational missiles in the Agni series: Agni-I, Agni-II, Agni-III, Agni-IV, Agni-V, and Agni-Prime and one missile is under development (Agni-VI). Each missile has different ranges and capabilities.

1. Agni-I

  • Agni-I is the shortest-range and oldest missile in the Agni family of Indian nuclear-capable missiles. It was first tested at the Chandipur test range, off the coast of Odisha in 1989.
  • It is a two-stage solid-fuel missile that can be stored in canisters and transported by road and rail.
  • Range: 700 km
  • The missile has a specialised navigation system that ensures it reaches the target with a high degree of accuracy and precision.
  • Agni-I is used by the Strategic Force Command (SFC) of the Indian Army. 

2. Agni-II

  • The Agni-II is a medium-range ballistic missile equipped with two solid fuel stages.
  • Range: 2000-2500 km
  • They are said to be a component of "credible deterrence" against China and Pakistan.

3. Agni-III

  • Agni-III is a two-stage ballistic missile that can carry nuclear weapons.
  • Range: 3500 km

4. Agni-IV

  • It is an Intermediate Range Ballistic Missile which uses a two-stage rocket engine powered by solid propellants.
  • Range: 4000 km 
  • It is equipped with state-of-the-art avionics, an accurate Ring Laser Gyro-based Inertial Navigation System, supported by the highly reliable redundant Micro Navigation System for high precision. 

5. Agni-V

  • The Agni 5 is the first of its kind inter-continental ballistic missile (ICBM) of India. 
  • It is a three-stage solid-rocket-powered missile system capable of delivering a 1.5-tonne nuclear warhead.
  • Range: exceeding 5000 km
  • Agni-V can bring almost the entire Asia, including the northernmost part of China, as well as some regions in Europe, under its striking range.
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6. Agni-P

  • The Agni Prime missile is a new-generation advanced variant of the Agni class of missiles.
  • The two-stage canisterised ballistic missile has a range between 1000 and 2000 kilometres.
  • It is India's first 'declared' MIRV (Multiple Independently-targetable Reentry Vehicles) missiles, and it is 50% lighter than Agni-III.
  • Agni-Prime may be launched from train and road and stored for an extended period. It can be used to target enemy ships in the Indian Ocean.

7. Agni-VI

  • Agni-VI is a three-stage solid-fuel intercontinental ballistic missile in the early phases of development in India.
  • It will be able to launch from both submarines and land and carry independently targetable re-entry vehicles (MIRV) payloads. 
  • Range: 8000-10000 km 

Scientists discover a virgin birth (Parthenogen) in a crocodile

Context: Recently female crocodile in a Costa Rican zoo laid a clutch of eggs. That was peculiar: She’d been living alone for 16 years.

How does a virgin birth happen?

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  • As an egg cell matures in its mother’s body, it divides repeatedly to generate a final product with exactly half the genes needed for an individual.
  • Three smaller cellular sacs containing chromosomes, known as polar bodies, are formed as byproducts. Polar bodies usually wither away.
  • But in vertebrates that can perform parthenogenesis, one polar body sometimes fuses with the egg, creating a cell with the necessary complement of chromosomes to form an individual.
  • This process of Vergine birth (offspring containing only genetic material from its mother) is known as parthenogenesis

Parthenogenesis can be seen in the following creatures

  • King cobras
  • Sawfish
  • California condors
  • Crocodile
  • Some birds
  • Lizards

Why parthenogenesis occurs?

  • It’s possible that parthenogenesis gives a species the ability to survive extended periods when no mate is available.
  • A fresh individual, bearing largely the same genes as its parent, might live long enough for a mate to arrive, thus allowing sexual reproduction, which tends to produce hardier offspring.
  • But it is also possible that parthenogenesis is simply a trait that doesn’t have enough downsides for evolution to weed it out.
  • It is not necessarily a response to stress or even a lack of mates. In 2020, scientists discovered that lizards can mate and then lay clutches of eggs where some are normal offspring and some are parthenogens.
  • It’s an ability that can be switched on or off, and it is perhaps controlled by a single gene.

Scientists X-ray a single atom for the first time

Context: Scientists, for the first time, have identified an element by X-raying a single atom of a material. 

Scientists X-ray a single atom for the first time

The experiment

  • X-rays are an important way to identify the type of material. Until the recent experiment,  the minimum sample size required was roughly 10,000 atoms.
    • The minimum amount of material was required as an atom’s response to being hit by X-rays can be very weak. Hence, the more atoms, the better detectors can pick up on their response.
  • For the experiment, the scientists used a method called synchrotron X-ray scanning tunnelling microscopy or SX-STM. The scientists modified a conventional X-ray detector to add a sharp metal tip that would be moved to be extremely close to a sample (as close as 0.5 nanometres from the atom). This is to improve the detector’s ability to record any signals from the atom.
  • The sample’s atom was hit with X-ray photons. The electrons in the atom absorbed only photons of certain frequencies. Using a spectroscope, the team determined which frequencies had been absorbed and hence, identified the element. (Every element has a unique absorption spectrum which can be used to identify it).

Significance:

  • Identification of a material using only one atom can revolutionise research in material science, quantum mechanics, and other areas.
  • The study also characterised the chemical states of the atoms and will help understand their properties better, which would help researchers manipulate the atoms to greater precision.

About X-rays

  • X-Rays or X-radiation is a form of high-energy electromagnetic radiation. They have a wavelength ranging from 0.01 to 10 nanometres, frequencies in the range 3 × 10^19 Hz to 3×10^16 Hz and energies in the range of 100 eV to 100 keV.
  • X-rays are generated when high-energy electrons interact with matter. X-ray photons carry enough energy to ionize atoms and disrupt molecular bonds. 
  • A very high radiation dose of X-ray over a short period causes radiation sickness, while lower doses can give an increased risk of radiation-induced cancer. 

Applications:

  • X-rays are used in checking for fractures (broken bones), spotting pneumonia (chest X-rays), spotting cancer (Mammograms) and detecting tumours. 
  • Ionizing capability of X-rays can be utilized in cancer treatment to kill malignant cells using radiation therapy. 
  • X-rays have much shorter wavelengths than visible light, which makes it possible to probe structures much smaller than can be seen using a normal microscope. This property is used in X-ray microscopy to acquire high-resolution images, and also in X-ray crystallography to determine the positions of atoms in crystals.
  • X-rays are also used for material characterization using X-ray spectroscopy.
  • X-rays can travel through a vacuum (propagate through empty space without requiring a medium). This property allows X-rays to be used in space exploration and research conducted in vacuum chambers.
  • X-rays are used in security systems, such as airport scanners, to detect objects hidden within luggage or on a person's body.

Will the WHO’s ‘pandemic treaty’ leave out antimicrobial resistance?

Context: Recently, the latest version of the draft Pandemic Instrument or the pandemic treaty was shared with member states at the World Health Assembly. While earlier drafts of the Pandemic Instrument drew on guidance from Antimicrobial resistance (AMR) policy researchers and civil society organizations, but after the closed-door negotiations by member states, these insertions are at risk for removal.

Anti-Microbial Resistance: 

antimicrobial treatments
  • Antimicrobial resistance (AMR) is the process by which infections caused by microbes become resistant to medicines/antimicrobial treatments (such as antibiotics, antifungals, antivirals, antimalarials, and anthelmintics) developed to treat them.
    • Microbes include bacteria, fungi, viruses and parasites. 
  • As a result, traditional therapies are rendered ineffective, illnesses persist, and the risk of spreading the infection to others increases. Antimicrobial-resistant microorganisms are frequently referred to as "superbugs." 

Factors contributing to AMR: 

  • Misuse of antibiotics by buying over-the-counter/wrong prescription. Widespread use of antibiotics over the last years due to COVID-19. 
  • Rampant use of antibiotics in agriculture and farming sector. E.g., Streptomycin used for treating Tuberculosis is used indiscriminately to grow fruits & vegetables, Colistin is mixed in poultry feed to make chickens grow faster.  
  • Untreated waste from pharmaceutical manufacturing sites and hospitals releases large amounts of active antimicrobials into the environment.
  • Incomplete course of antimicrobial drugs may develop drug resistance. E.g., MDR-Tuberculosis. 
  • Lack of hygiene and sanitation, infrastructural standards such as quality of drinking water and sanitation levels also contribute to AMR. 

Rising Risk due to AMR:

  • AMR is fueling the rise of drug-resistant infections, including:
    • drug-resistant tuberculosis
    • drug-resistant pneumonia
    • drug-resistant Staph infections such as methicillin-resistant Staphylococcus aureus (MRSA). 

AMR has made it harder to treat such infections and also, adds to the burden of communicable diseases and strains the health systems of a country.

  • AMR has been named one of the top ten global health hazards by the World Health Organisation (WHO).
    • In 2019, AMR was associated with an estimated 4.95 million human deaths.
    • A 2018 report by the Organisation for Economic Co-operation and Development (OECD) warned of a phenomenal increase in resistance to backup antibiotics (second and third-line) by 2030. 
  • AMR imposes a huge health cost on the patient in the form of longer hospitalisation, health complications and delayed recovery. It puts patients undergoing major surgeries and treatments, such as chemotherapy, at a greater risk. 

The Pandemic Instrument: 

  • In December 2021, the 194 World Health Organization (WHO) Member States agreed to draft and negotiate an international pandemic instrument/treaty. 
  • Aim: To strengthen and coordinate national and international efforts to prevent, prepare for, and respond to future pandemic emergencies.

Concern:

  • However, the draft Pandemic Instrument is overly focused on viral threats and has ignored the “silent” pandemic of antimicrobial resistance and bacterial threats.
  • But, it is a cause of concern as not all pandemics in the past have been caused by viruses and not all pandemics in the future will be caused by viruses. E.g., Plague and cholera have been devastating past pandemics due to bacteria.
    • Even in the case of a viral pandemic, secondary bacterial infections will be a serious issue. E.g., COVID-19 patients were associated with pneumonia — a secondary bacterial infection that must be treated with antibiotics. 

Way Forward:

  • The “pandemic treaty” must plan, prepare and develop effective tools to respond to a wider range of pandemic threats, not solely viruses. Hence, there is a need to include bacterial pathogens in the definition of “pandemics”. 
  • AMR exceeds the capacity of any single country or sector to solve. Global political action is needed to ensure the international community works together to collectively mitigate AMR and support the conservation, development and equitable distribution of safe and effective antimicrobials.
  • Treating bacterial infections requires effective antibiotics, and with AMR increasing, effective antibiotics are becoming a scarce resource. Hence, more government investment in research and innovation is needed to develop new antibiotics.  

Malware Attack

Context: Recently a malware attack was detected by the cyber security team of the All India Institute of Medical Science (AIIMS), and was later thwarted and neutralised by the team.

What is a Malware Attack?

A malware attack is a common cyberattack where malware (normally malicious software) executes unauthorized actions on the victim’s system. Malicious software (a.k.a. viruses) encompasses many specific types of attacks such as ransomware, spyware, command and control, and more.

Criminal organizations, state actors, and even well-known businesses have been accused of (and, in some cases, caught) deploying malware. Like other types of cyber attacks, some malware attacks end up with mainstream news coverage due to their severe impact. An example of a famous malware attack is the WannaCry ransomware attack.

Malware Attacks Examined

Malware discussion typically encompasses three main aspects:

  • Objective: What the malware is designed to achieve
  • Delivery: How the malware is delivered to the target
  • Concealment: How the malware avoids detection (this item is beyond the scope of this discussion)

Here’s a breakdown of some of the objectives and delivery mechanisms observed in malware.

Objectives

Malware is created with an objective in mind. While it could be said that the objective is “limited only to the imagination of its creator,” this will focus on some of the most common objectives observed in malware.

  • Exfiltrate Information: Stealing data, credentials, payment information, etc. is a recurring theme in the realm of cybercrime. Malware focused on this type of theft can be extremely costly to a person, company, or government target that falls victim.
  • Disrupt Operations: Actively working to “cause problems” for a target’s operation is another objective seen in malware. From a virus on a single computer corrupting critical OS files (making that one system unusable) to an orchestrated, physical self-destruction of many systems in an installation, the level of “disruption” can vary. And there’s also the scenario where infected systems are directed to carry out large-scale distributed denial of service (DDOS) attacks.
  • Demand Payment: Some malware is focused on directly extorting money from the target. Scareware uses empty threats (ones that are unsubstantiated and/or couldn’t be carried out) to “scare” the target into paying some money. Ransomware is a type of malware that attempts to prevent a target from accessing their data (usually by encrypting files on the target) until the target “pays up.” While there is debate over whether victims of ransomware should or should not pay, it has become enough of a threat that some companies have preemptively purchased Bitcoin just in case they get hit with ransomware and decide to pay the ransom.

Types of Malware Attack Vectors

There are three main types of malware attack vectors:

  • Trojan Horse: This is a program that appears to be one thing (e.g. a game, a useful application, etc.) but is a delivery mechanism for malware. A trojan horse relies on the user to download it (usually from the internet or via email attachment) and run it on the target.
  • Virus: A virus is a type of self-propagating malware that infects other programs/files (or even parts of the operating system and/or hard drive) of a target via code injection. This behaviour of malware propagation through injecting itself into existing software/data is a differentiator between a virus and a trojan horse (which has purposely built malware into one specific application and does not make attempts to infect others).
  • Worm: Malware designed to propagate itself into other systems is a worm. While virus and trojan horse malware are localized to one infected target system, a worm actively works to infect other targets (sometimes without any interaction on the user’s behalf).

Over the years, malware has been observed to use a variety of different delivery mechanisms, or attack vectors. While a few are admittedly academic, many attack vectors are effective at compromising their targets. These attack vectors generally occur over electronic communications such as email, text, vulnerable network service, or compromised website, malware delivery can also be achieved via physical media (e.g. USB thumb drive, CD/DVD, etc.).

Best Practices Against Malware Attacks

The following best practices can help prevent a malware attack from succeeding and/or mitigate the damage done by a malware attack.

  • Continuous User Education: Training users on best practices for avoiding malware (i.e. don’t download and run unknown software, don’t blindly insert “found media” into your computer), as well as how to identify potential malware (i.e. phishing emails, unexpected applications/processes running on a system) can go a long way in protecting an organization. Periodic, unannounced exercises, such as intentional phishing campaigns, can help keep users aware and observant. Learn more about security awareness training.
  • Use Reputable A/V Software: When installed, a suitable A/V solution will detect (and remove) any existing malware on a system, as well as monitor for and mitigate potential malware installation or activity while the system is running. It’ll be important to keep it up-to-date with the vendor’s latest definitions/signatures.
  • Ensure Your Network is Secure: Controlling access to systems on your organization’s network is a great idea for many reasons. The use of proven technology and methodologies—such as using a firewall, IPS, IDS, and remote access only through VPN—will help minimize the attack “surface” your organization exposes. Physical system isolation is usually considered an extreme measure for most organizations and is still vulnerable to some attack vectors.
  • Perform Regular Website Security Audits: Scanning your organization’s websites regularly for vulnerabilities (i.e. software with known bugs, server/service/application misconfiguration) and detecting if known malware has been installed can keep your organization secure, protect your users, and protect customers and visitors for public-facing sites.
  • Create Regular, Verified Backups: Having a regular (i.e. current and automated) offline backup can be the difference between smoothly recovering from a destructive virus or ransomware attack and stressful, frantic scrambling with costly downtime/data loss. The key here is to have regular backups that are verified to be happening on the expected regular basis and are usable for restoration operations. Old, outdated backups are less valuable than recent ones, and backups that don’t restore properly are of no value.

DNA Sampling

Context: In the tragic railway accident that took place in Balasore in Odisha, the administration is facing a challenge of identifying people. In order to identify people, A DNA testing centre has been created at AIIMS to identify people and give the bodies to respective family members.

What is DNA Sampling?

DNA sampling refers to the collection and analysis of DNA (deoxyribonucleic acid) samples from individuals. DNA is the genetic material that carries the instructions for the development and functioning of living organisms.

What are the ways to collect DNA Sample?

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Following are the ways to collect DNA sample:

  • By collecting cheek swab
  • By drawing blood
  • By taking saliva sample
  • In new born, through heel prick
  • Amniocentesis for pregnant women
  • Chorionic villus sampling for 10-13 week old featus
  • Fine needle aspiration

For forensic studies, DNA is collected from following sources:

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DNA sampling is used in various contexts, including forensic investigations, paternity testing, and medical research. Here's how it is commonly used to identify people:

  1. Forensic DNA Sampling: In criminal investigations, DNA sampling plays a crucial role in identifying suspects and linking them to crime scenes. Investigators collect DNA samples from various sources such as blood, saliva, hair, or skin cells left at the scene. These samples are then sent to a laboratory for analysis.
  1. DNA Profiling: The collected DNA samples are subjected to a process called DNA profiling or DNA fingerprinting. This process involves analyzing specific regions of the DNA sequence that exhibit variations between individuals, known as polymorphic regions or genetic markers.
  1. Polymerase Chain Reaction (PCR): PCR is a technique used to amplify specific DNA regions in the collected samples. This amplification process generates sufficient DNA material for further analysis.
  1. Short Tandem Repeat (STR) Analysis: STR analysis is commonly used in forensic DNA profiling. It involves identifying and comparing the lengths of short repeated sequences of DNA at specific loci. These repetitive sequences vary among individuals, making them useful for distinguishing between people.
  1. DNA Database Comparison: Once the DNA profile is obtained, it can be compared to profiles stored in DNA databases. These databases contain DNA profiles from known individuals, such as convicted criminals or missing persons. If a match is found, it can provide important investigative leads or help confirm a person's identity.
  1. Paternity Testing: DNA sampling is also used in paternity testing to determine biological relationships between individuals. The DNA profiles of the child and potential parents are compared, and the likelihood of paternity is assessed based on the degree of similarity.

It's important to note that DNA sampling and analysis require careful handling and adherence to strict protocols to ensure accuracy and avoid contamination. The results obtained from DNA testing can provide strong evidence in various legal, medical, and identity-related situations.

m-RNA Vaccine for Cancer

Context: An experimental mRNA-based vaccine from Moderna Inc and Merck & Co reduced the risk of melanoma spread by 65% when compared with immunotherapy alone in a mid-stage trial the results, presented at the American Society of Clinical Oncology meeting in Chicago.

m-RNA Vaccine for Cancer

About m-RNA

  • Messenger RNA (mRNA) is a type of single-stranded RNA involved in protein synthesis. 
  • It is made from a DNA template during the process of transcription. 
  • The role of mRNA is gene expression and to carry protein information from the DNA in a cell’s nucleus to the cell’s cytoplasm (watery interior).
  • It carries the genetic information from DNA (deoxyribonucleic acid) to the ribosomes, where proteins are synthesized.
  • DNA is transcribed into mRNA, which is then translated into proteins. mRNA acts as an intermediary between DNA and proteins, carrying the genetic instructions encoded in the DNA to the protein-making machinery of the cell.

m-RNA Vaccine

  • Vaccines help prevent infection by preparing the body to fight foreign invaders (such as bacteria, viruses, or other pathogens).
  • m-RNA vaccine delivers molecules of antigen-encoding mRNA into immune cells, which use designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen (such as a virus) or by a cancer cell. 
  • These protein molecules stimulate an adaptive immune response that teaches the body to identify and destroy the corresponding pathogen or cancer cells.

How does it work?

  • An mRNA vaccine uses a copy of mRNA to produce an immune response. 
  • The vaccines target neoantigens, new mutations only present on tumors. 
  • Aiming at these proteins allows the immune system to kill cancer cells while leaving healthy tissue unscathed. The trick is determining which of many mutations is driving the cancer.
  • To accomplish this, tumors are removed and their genetic makeup is mapped using DNA sequencing.
  • Companies use artificial intelligence to predict which mutations will be effective targets. These are used to build an individualised vaccine targeting only mutations in the patient's tumor.

Benefits

  • mRNA vaccines are not constructed from an active pathogen (or even an inactivated pathogen), they are non-infectious. In contrast, traditional vaccines require the production of pathogens, which, if done at high volumes, could increase the risks of localized outbreaks of the virus at the production facility.
  • mRNA vaccines could trigger the innate immune system (the immunity we’re born with), providing an extra layer of defence.
  • mRNA vaccines can be developed and manufactured quickly compared to traditional vaccines. Once the genetic sequence of a target antigen is known, the production of mRNA can be initiated promptly.
  • mRNA vaccines are highly versatile. They can be designed to target various pathogens by simply changing the mRNA sequence to encode the desired antigen.

Challenges

  • Storage: Because mRNA is fragile, some vaccines must be kept at very low temperatures to avoid degrading and thus giving little effective immunity to the recipient.
  • Adverse reaction: Excessive immunological responses and associated signs and symptoms, including fever and sore arm at the injection site are associated with mRNA vaccine.
  • Manufacturing Scalability: The manufacturing processes, including the production and purification of mRNA molecules, require sophisticated technology and expertise.

Transcription

  • The process by which a cell makes an RNA copy of a piece of DNA. This RNA copy, called messenger RNA (mRNA), carries the genetic information needed to make proteins in a cell.

Gene expression 

  • The process by which the information encoded in a gene is used to synthesize a functional gene product, such as a protein or a non-coding RNA molecule.