Context: The World Health Organization’s Global Antibiotic Resistance Surveillance Report (2025) warns that nearly 1 in 6 bacterial infections worldwide in 2023 were resistant to antibiotics. Between 2018–2023, resistance rose in over 40% of pathogen–antibiotic combinations, with an annual increase of 5–15%, signaling an accelerating global health emergency.
What is Antimicrobial Resistance (AMR)?
Antimicrobial Resistance (AMR) occurs when microorganisms (bacteria, viruses, fungi, parasites) evolve to resist the effects of drugs designed to kill them.
- Example: Multi-Drug-Resistant Tuberculosis (MDR-TB) — caused by Mycobacterium tuberculosis resistant to both isoniazid (INH) and rifampicin (RMP).
- AMR makes infections harder to treat, increases hospital stays, and raises mortality risk.
Key Findings from WHO Report (2025):
- Scale of Resistance:
Globally, 16% of lab-confirmed infections were antibiotic-resistant in 2023. The highest rates are reported from South-East Asia and the Eastern Mediterranean, where 1 in 3 infections show resistance. - Most Affected Pathogens (8 major bacteria):
E. coli, Klebsiella pneumoniae, Acinetobacter spp., Salmonella spp., Shigella spp., Staphylococcus aureus, Streptococcus pneumoniae, Neisseria gonorrhoeae. - Drug Resistance Pattern:
Over 40% of E. coli and 55% of Klebsiella pneumoniae strains are resistant to 3rd-generation cephalosporins, a mainline antibiotic group. - Data Gaps:
Nearly 48% of countries did not report sufficient data to the Global AMR Surveillance System (GLASS), reflecting weak diagnostic capacity and reporting infrastructure.
India’s Perspective
India faces one of the highest burdens of AMR globally.
- Causes: Overuse of antibiotics, self-medication, poor infection control, and use of antibiotics in livestock.
- Initiatives:
- National Action Plan on AMR (2017–2025).
- AMR Surveillance & Research Network (ICMR).
- “One Health” approach integrating human, animal, and environmental health.
Way Forward
- Stewardship: Rational antibiotic prescription and public awareness.
- Surveillance: Strengthen global and national reporting systems.
- Research: Promote new antibiotics, vaccines, and alternatives like phage therapy.
- Global Cooperation: Coordinated policy response under WHO and UN frameworks.
Conclusion
Antibiotic resistance is not just a medical challenge—it is a societal threat jeopardizing modern medicine. Strengthening surveillance, promoting responsible use, and fostering global partnerships remain key to reversing the tide of AMR.




