Context: The Axiom-4 Mission to the International Space Station (ISS) was launched on June 25, 2025 to conduct scientific research, outreach and commercial activities in space. Shubhanshu Shukla, an Indian Air Force (IAF) officer and ISRO astronaut piloted the Mission.
Relevance of the Topic: Prelims: Key facts about Axiom-4 Mission; ISRO’s Experiments in Axiom-4 Mission.
Axiom-4 Mission is a private spaceflight organised by Axiom Space. The crew will spend about 14 days aboard the International Space Station (ISS) and conduct various experiments in the microgravity environment.
Key ISRO’s Experiments in Axiom-4 Mission
1. Myogenesis Study:
- Shukla performed operations in Life Sciences Glovebox (LSG) for the Myogenesis study.
- Aim: To uncover the molecular mechanisms driving muscle loss in space.
- Significance: These findings could also pave the way for:
- Targeted treatments to prevent muscle atrophy during prolonged space missions.
- New therapies to address muscle-wasting conditions on Earth such as those related to ageing or immobility.
Myogenesis:
- Myogenesis is the biological process through which muscle tissue is formed during early stages of embryonic development from stem cells. These stem cells gradually differentiate into muscle precursor cells, which then multiply and fuse together to form muscle fibres.
- Myogenesis is crucial for the growth of the body, repair of muscle tissue, and regeneration of the musculoskeletal system (which includes bones, muscles and connective tissues).
2. Growing Sprouts and Moong Beans:
- The Sprouts-ISRO experiment focuses on the growth of green gram (moong) and fenugreek (methi) seeds in space. These are staple, nutrient-rich foods in India.
- Aim: To study how microgravity affects their germination, genetics, and nutritional content.
- Significance: Understanding these changes can help in:
- Developing reliable plant-based food systems for future space missions.
- Supporting agricultural advancements on Earth, particularly in resource-constrained or extreme environments where conventional farming is difficult.
3. Microalgae Experiment:
- Aim: To study how Microalgae grow and evolve in the absence of gravity.
- Microalgae are highly efficient organisms known for producing oxygen, absorbing carbon dioxide, and providing dense nutrition.
- Significance:
- If successful, microalgae could become a sustainable food source for long-duration space missions.
- Open up possibilities for using them in Earth-based environmental and food solutions, especially in areas with limited access to resources.
4. Survival of Tardigrades in Space:
- The Voyager Tardigrade-ISRO experiment aims to observe how tardigrades survive and reproduce in extreme space conditions and compare their gene expression with Earth-based samples.
- Tardigrades are tiny aquatic creatures that can survive radiation, vacuum, and freezing temperatures.
- Significance: The research will decode the biology behind their resilience, which could lead to innovations in radiation protection for astronauts, and even new materials or therapies for use in harsh environments on Earth.
5. Human interaction with Technology in Microgravity:
- Voyager Displays-ISRO explores how spaceflight alters human interaction with electronic interfaces like touchscreens. Tasks involving gaze, touch, and eye movement will be analysed to understand cognitive and motor changes caused by microgravity.
- Significance:
- To improve the design of control systems for spacecraft and future space habitats.
- The results may also benefit high-stress environments on Earth, such as aviation or emergency response, where quick, intuitive interaction with digital systems is crucial for safety and performance.
6. Cerebral Hemodynamics Study:
- Using Ultrasound technology, ISRO and NASA will explore how blood circulates in the brain under microgravity conditions.
- Significance: The findings could improve our understanding of cardiovascular adaptation in space and inform medical diagnostics and treatments for conditions like stroke and hypertension on Earth.
The experience gained through the experiments is expected to nurture a microgravity research ecosystem in India resulting in the induction of advanced microgravity experiments in various disciplines in the Indian space programme.
Also Read: Indian Astronaut to pilot Axiom Mission 4












