Context: Researchers have discovered thermophilic bacteria capable of producing antimicrobial compounds, particularly from the Actinobacteria group in the Rajgir hot spring in Bihar.
Relevance of the Topic: Prelims: Key facts of Thermophiles bacteria.


Thermophilic Bacteria
- Thermophiles are heat-loving bacteria that can survive in extreme temperatures ranging from 45°C to 70°C. They thrive in hot springs, deep-sea vents, and compost piles, etc.
- To compete with other microbes, some thermophiles produce strong antibiotics. These antibiotics kill or suppress other bacteria, helping thermophiles survive better.
Findings from Rajgir Hot Spring Study:
- Using a method called 16S rRNA metagenomics, researchers identified one major group of bacteria- Actinobacteria.
- Actinobacteria constituted 40-43% of the microbial diversity in the lake, a much higher share than typically observed in hot springs (generally ~20%).
- This group of bacteria is well-known for producing antibiotics like streptomycin, tetracycline, and erythromycin. However, not all thermophiles can produce antibiotics.
- Seven strains of Actinobacteria were found that produced potent antimicrobial compounds. These antimicrobial compounds are capable of inhibiting the growth of several pathogenic bacteria, including E. coli, Salmonella typhimurium, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus.
- Researchers have succeeded in isolating a compound called diethyl phthalate from Actinomycetales bacteria found in the hot spring. Using gas chromatography-mass spectrometry (GC-MS), they identified its antibacterial activity against Listeria monocytogenes, a serious foodborne pathogen. This finding highlights the potential use-case of hot spring microbes.

Significance of Thermophiles:
- Produce antibiotics: Discovering antibiotic-producing thermophiles offers a promising solution to combat antimicrobial resistance, which could add $1 trillion to global healthcare costs by 2050.
- Produce enzymes for diagnostics: Enzymes from thermophiles like Thermus aquaticus are used in PCR testing, which became a backbone of COVID-19 diagnostics.
- Heat-resistant enzymes from thermophiles are used in biotechnology, molecular biology, and chemical industries.
- Biofertilisers: A 2018 study by Banaras Hindu University found that thermophiles from Chumathang hot spring in Leh enhanced plant growth, suggesting application in biofertilisers and heat-stress resistant crops.






